DNA
DNA stores the instructions for protein synthesis in the nucleus
mRNA
Proteins are the foundation of life, carrying out the essential functions required by every cell
Protein
mRNA-based drugs deliver a precise genetic message into the cells, instructing them to produce any type of protein
The ability to set instructions for cells allows mRNA therapeutics to be used for treating any disease
mRNA drugs have the potential to transform the standards of drug discovery and manufacturing
mRNA consists of a coding region, which contains all the information about protein sequence, and several regulatory elements that stabilize the mRNA and guide the protein production machinery to mRNA
These elements include the mRNA cap at the 5′ end and the polyA tail at the 3′ end of mRNA.
The 5’ cap is a natural mRNA modification that stabilizes mRNA and plays an essential role in translation initiation (the process that leads to protein production from mRNA).
Synthetic modifications of the 5′ cap enable further improvement of mRNA therapeutic properties by increasing its stability and increasing translation efficiency. ExploRNA co-founders have previously developed mRNA cap analogs that improve biological properties of mRNA.
Today we are introducing the next generation of capping reagents featuring groundbreaking biological properties.
Using mRNA as a therapeutic is a cutting-edge approach
mRNA based drugs deliver a defined generic message into the cells to produce any kind of protein
Ability to set instruction for cells allows mRNA therapeutics to be used for any disease
mRNA drugs have potential to transform standards of drug discovery and manufacturing
Significantly increase protein yield in vivo over standard capping reagents
Re compatible with standard co-transcriptional capping procedure
Increase protein expression of both unmodified and uridine-modified mRNA
Facilitate mRNA purification
Are easy to manufacture
mRNA technology has emerged as both a disruptive and highly promising new class of medicines.
The latest innovations in mRNA technology, combined with the unique expertise of ExploRNA’s scientific team, offer a significant opportunity to harness this cutting-edge technology platform to revolutionize therapy and prevention of many diseases.
ExploRNA’s two lead development programs are focusing on tumor specific antigen vaccines and the expression of cytokines to promote cytotoxic T cells to eliminate tumor growth.
ExploRNA builds a strong intellectual property position based on science excellence.
International patents
5'-phosphorothiolate mRNA 5'-end (cap) analogs, mRNA comprising the same, method of obtaining and uses thereof
Novel phosphotriazole mRNA 5'-end cap analogs, composition comprising the same, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule, protein or peptide
Novel mRNA 5'-end cap analogs modified within phosphate residues, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide
Novel mRNA 5'-end cap analogs, RNA molecule incorporating the same, uses thereof and method of synthesizing RNA molecule or peptide
